J Allergy Clin Immun：尿液双酚A浓度与儿童哮喘相关

2013-03-05 高晓方 译 医学论坛网

尿液双酚A浓度儿童哮喘

　　美国学者的一项研究表明，出生后尿液双酚A浓度与儿童哮喘具有相关性。论文发表于《变态反应和临床免疫学杂志》[J Allergy Clin Immun 2013; 131(3):736]。 　　此项研究共纳入568例妊娠女性，并对受试女性及其子女进行了前瞻性随访。在妊娠晚期采集母亲尿样，在3、5和7岁时采集儿童尿样。利用固相萃取、高效液相色谱法和

　　美国学者的一项研究表明，出生后尿液双酚A浓度与儿童哮喘具有相关性。论文发表于《变态反应和临床免疫学杂志》[J Allergy Clin Immun 2013; 131(3):736]。

　　此项研究共纳入568例妊娠女性，并对受试女性及其子女进行了前瞻性随访。在妊娠晚期采集母亲尿样，在3、5和7岁时采集儿童尿样。利用固相萃取、高效液相色谱法和同位素稀释串联质谱法测定总尿液双酚A浓度。利用5、6和7岁时调查问卷评估终末12个月的哮鸣情况。在5至12岁期间由医生确定哮喘。在7至11岁期间测定呼出气一氧化氮（FeNO）。

　　结果显示，出生前尿液双酚A浓度与5岁时哮鸣呈负相关（比值比[OR] 0.7；P=0.02）。3岁时尿液双酚A浓度与5岁和6岁时哮鸣呈正相关。7岁时双酚A浓度与7岁时哮鸣和FeNO值具有相关性。3、5和7岁时双酚A浓度与哮喘具有相关性（OR分别为1.5、1.4和1.5）。

与哮喘相关的拓展阅读：


Prenatal and postnatal bisphenol A exposure and asthma development among inner-city children

Background
Bisphenol A (BPA) is used widely to manufacture food container linings. Mouse models suggest exposure to BPA might increase allergic inflammation.
Objectives
We hypothesized that BPA exposure, as assessed based on urinary BPA concentrations, would be associated with increased odds of wheeze and asthma and increased fraction of exhaled nitric oxide (Feno) values in children.
Methods
The Columbia Center for Children's Environmental Health recruited pregnant women for a prospective birth cohort study (n = 568). Mothers during the third trimester and children at ages 3, 5, and 7 years provided spot urine samples. Total urinary BPA concentrations were measured by using online solid-phase extraction, high-performance liquid chromatography, isotope-dilution tandem mass spectrometry. Wheeze in the last 12 months was measured by using questionnaires at ages 5, 6, and 7 years. Asthma was determined by a physician once between ages 5 and 12 years. Feno values were measured at ages 7 to 11 years.
Results
Prenatal urinary BPA concentrations were associated inversely with wheeze at age 5 years (odds ratio [OR], 0.7; 95% CI, 0.5-0.9; P = .02). Urinary BPA concentrations at age 3 years were associated positively with wheeze at ages 5 years (OR, 1.4; 95% CI, 1.1-1.8; P = .02) and 6 years (OR, 1.4; 95% CI, 1.0-1.9; P = .03). BPA concentrations at age 7 years were associated with wheeze at age 7 years (OR, 1.4; 95% CI, 1.0-1.9; P = .04) and Feno values (β = 0.1; 95% CI, 0.02-0.2; P = .02). BPA concentrations at ages 3, 5, and 7 years were associated with asthma (OR, 1.5 [95% CI, 1.1-2.0], P = .005; OR, 1.4 [95% CI, 1.0-1.9], P = .03; and OR, 1.5 [95% CI, 1.0-2.1], P = .04, respectively).
Conclusions
This is the first report of an association between postnatal urinary BPA concentrations and asthma in children.

    

作者：高晓方 译



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