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[GetTopicListResponse(id=2220366, encodeId=620522203660a, content=<a href='/topic/show?id=41651083831e' target=_blank style='color:#2F92EE;'>#Vorasidenib#</a>是由<a href='/topic/show?id=1ba85880eda' target=_blank style='color:#2F92EE;'>#施维雅#</a>公司开发的<a href='/topic/show?id=4942941e83' target=_blank style='color:#2F92EE;'>#IDH1#</a>和IDH2突变酶的双重抑制剂，可通过口服给药，能够穿越血脑屏障，到达<a href='/topic/show?id=53668406668' target=_blank style='color:#2F92EE;'>#胶质瘤#</a>部位，大幅提高患者的生存!! <a href='/topic/show?id=b35011e938cd' target=_blank style='color:#2F92EE;'>#沃拉西尼#</a> , objectTitle=NEJM：20多年来胶质瘤治疗的首个重大突破，大幅延长患者生存期, objectType=article, longId=775467, objectId=fe17e7546715, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230606/1686014563030_5295905.jpg, objectUrl=/article/show_article.do?id=fe17e7546715, replyNumber=0, likeNumber=76, createdTime=2024-08-15, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=威斯康星, 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ipAttribution=上海, moduleDTOList=null, followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2161857, encodeId=de06216185e1e, content=高达50%的<a href='/topic/show?id=e37c83513be' target=_blank style='color:#2F92EE;'>#胆管癌#</a>可能是<a href='/topic/show?id=877631e09af' target=_blank style='color:#2F92EE;'>#分子靶向治疗#</a>的潜在受益者。几项规模较小的临床试验显示了二线以上靶向治疗的潜力。比如<a href='/topic/show?id=5ae0e40125' target=_blank style='color:#2F92EE;'>#FGFR2#</a>、<a href='/topic/show?id=f5d71312e50' target=_blank style='color:#2F92EE;'>#NTRK#</a>、<a href='/topic/show?id=4942941e83' target=_blank style='color:#2F92EE;'>#IDH1#</a>、<a href='/topic/show?id=6de63659ed' target=_blank style='color:#2F92EE;'>#BRAF#</a>、<a href='/topic/show?id=e3818e1893' target=_blank style='color:#2F92EE;'>#HER2#</a>等<a href='/topic/show?id=e6924180936' target=_blank style='color:#2F92EE;'>#基因突变#</a>。以及<a href='/topic/show?id=85cd50561c3' target=_blank style='color:#2F92EE;'>#微卫星不稳定性#</a>MSI的情况，这些相关指标的检测也将会为胆管癌患者的精准治疗打下相应的治疗基础。事实上，其它<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>也是一样的，各个不同的肿瘤都应该按这个思路研究一遍，对于象<a href='/topic/show?id=33771982175' target=_blank style='color:#2F92EE;'>#三阴性乳腺癌#</a>，<a href='/topic/show?id=5e2e4e08988' target=_blank style='color:#2F92EE;'>#小细胞肺癌#</a>，<a href='/topic/show?id=08f236865a8' target=_blank style='color:#2F92EE;'>#卵巢癌#</a>，同样如此，梅斯各位会员们，你们如果有兴趣，要尽快研究，这是一个很好的方向，当然，也可以申请<a href='/topic/show?id=ca2e4095eaf' target=_blank style='color:#2F92EE;'>#国家自然科学基金#</a><a href='/topic/show?id=cebd410388c' target=_blank style='color:#2F92EE;'>#国自然基金#</a>, objectTitle=真实数据，高达50%的胆管癌是分子靶向治疗的潜在受益者，有机会活得更好、更长！, objectType=article, longId=794442, objectId=b596e944427e, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/busy-reception-in-a-hospital-with-doctors-and-PUPDEB8.jpg, objectUrl=/article/show_article.do?id=b596e944427e, replyNumber=0, likeNumber=165, 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objectTitle=NEJM：Ivosidenib治疗IDH1突变型AML疗效喜人, objectType=article, longId=139938, objectId=f21013993802, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=f21013993802, replyNumber=0, likeNumber=125, createdTime=2018-10-06, rootId=0, userName=ms6127405442416114, userId=be6531934024, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=f21013993802, moduleTitle=NEJM：Ivosidenib治疗IDH1突变型AML疗效喜人, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=f21013993802)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=1715482, encodeId=ba951e1548295, content=<a href='/topic/show?id=4942941e83' target=_blank style='color:#2F92EE;'>#IDH1#</a>, objectTitle=Leukemia：维生素C能诱导IDH1突变的急性髓系白血病的表观遗传修饰, objectType=article, longId=127599, objectId=099312e5996f, topicUrl=null, isHasObj=0, objectCover=null, objectUrl=/article/show_article.do?id=099312e5996f, replyNumber=0, likeNumber=115, createdTime=2018-07-29, rootId=0, userName=ms6127405442416114, userId=be6531934024, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=, moduleDTOList=[ModuleDTO(moduleId=099312e5996f, moduleTitle=Leukemia：维生素C能诱导IDH1突变的急性髓系白血病的表观遗传修饰, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=099312e5996f)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

IDH1

2020-05-29

侠胆医心 (审核中...)

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#Vorasidenib#是由#施维雅#公司开发的#IDH1#和IDH2突变酶的双重抑制剂，可通过口服给药，能够穿越血脑屏障，到达#胶质瘤#部位，大幅提高患者的生存!! #沃拉西尼#

NEJM：20多年来胶质瘤治疗的首个重大突破，大幅延长患者生存期

2024-08-15发表于威斯康星

梅斯管理员 (审核中...)

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#IDH1# #去甲基化酶# #2-羟基戊二酸#

2024-07-13发表于上海

侠胆医心 (审核中...)

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全文收起高达50%的#胆管癌#可能是#分子靶向治疗#的潜在受益者。几项规模较小的临床试验显示了二线以上靶向治疗的潜力。比如#FGFR2#、#NTRK#、#IDH1#、#BRAF#、#HER2#等#基因突变#。以及#微卫星不稳定性#MSI的情况，这些相关指标的检测也将会为胆管癌患者的精准治疗打下相应的治疗基础。事实上，其它#肿瘤#也是一样的，各个不同的肿瘤都应该按这个思路研究一遍，对于象#三阴性乳腺癌#，#小细胞肺癌#，#卵巢癌#，同样如此，梅斯各位会员们，你们如果有兴趣，要尽快研究，这是一个很好的方向，当然，也可以申请#国家自然科学基金##国自然基金#

真实数据，高达50%的胆管癌是分子靶向治疗的潜在受益者，有机会活得更好、更长！

2023-10-10发表于上海

ms6127405442416114 (审核中...)

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#IDH1#

NEJM：艾伏尼布联合阿扎胞苷治疗IDH1突变AML的3期研究结果公布，患者获益显著

2023-02-21

ms6127405442416114 (审核中...)

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#IDH1#

Neurology病例：Ollier病中经组织病理学证实的颅内内生软骨瘤/低级别软骨肉瘤和IDH1突变的弥漫性胶质瘤

2022-09-03

ms6127405442416114 (审核中...)

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#IDH1#

Clin Cancer Res：维奈托克+阿扎胞苷可显著改善IDH1/2突变AML患者的预后

2022-10-13

ms6127405442416114 (审核中...)

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#IDH1#

Clin Cancer Res：突变型IDH1/2双重抑制剂Vorasidenib治疗复发/进展胶质瘤的效果

2022-06-19

ms6127405442416114 (审核中...)

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#IDH1#

PNAS：雷公藤变成为靶向药物？有望用于治疗IDH1突变的癌症

2021-05-10

ms6127405442416114 (审核中...)

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#IDH1#

Clin Cancer Res：突变型IDH1/2双重抑制剂Vorasidenib治疗复发/进展胶质瘤的效果

2022-06-27

ms6127405442416114 (审核中...)

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#IDH1#

JAMA Oncol：Ivosidenib (AG-120)可改善经治IDH1突变肝内胆管细胞癌患者的总生存：III期ClarIDHy研究最终OS分析结果

2021-10-08

ms6127405442416114 (审核中...)

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#IDH1#

Blood：IDH1突变通过干扰血红素合成和红细胞生成导致髓系发育不良

2021-09-18

ms6127405442416114 (审核中...)

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#IDH1#

FDA批准抗肿瘤药物IDH1抑制剂HH2301临床试验

2020-08-14

ms6127405442416114 (审核中...)

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#IDH1#

Radiology：IDH1突变胶质瘤在超高分辨率3D MR波谱下会有什么发现？

2020-10-16

ms6127405442416114 (审核中...)

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#IDH1#

Lancet Oncol：Ivosidenib显著改善晚期mIDH1胆管癌患者的生存率

2021-10-17

ms6127405442416114 (审核中...)

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#IDH1#

Blood：DNMT3A和IDH1/2基因突变携带诱导血液恶性肿瘤的发生！

2020-11-24

ms6127405442416114 (审核中...)

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#IDH1#

Cell Death & Disease：前列腺癌中PAX5能够诱导IDH1-AS1上调来促进肿瘤的生长

2020-06-22

ms6127405442416114 (审核中...)

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#IDH1#

2019年ESMO：Ivosidenib显著改善晚期mIDH1胆管癌患者的生存率

2020-04-09

ms6127405442416114 (审核中...)

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#IDH1#

FDA批准**IDH1抑制剂用于治疗复发或难治性AML

2019-06-15

ms6127405442416114 (审核中...)

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#IDH1#

NEJM：Ivosidenib治疗IDH1突变型AML疗效喜人

2018-10-06

ms6127405442416114 (审核中...)

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#IDH1#

Leukemia：维生素C能诱导IDH1突变的急性髓系白血病的表观遗传修饰

2018-07-29

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